Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 5/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.36 |
| ▸ | RRM1 | P23921 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20615612 | 1.00 | PAOX (0.48) | PAOXSIRT6SIRT1MMP2KDM4E | |
| SCHEMBL19991828 | 0.84 | DPP7 (0.46) | PAOXSIRT6SIRT1DPP7RRM1 | |
| SCHEMBL18125223 | 0.84 | DPP7 (0.46) | PAOXSIRT6SIRT1DPP7RRM1 | |
| SCHEMBL22162694 | 0.81 | MMP2 (0.42) | PAOXSIRT6SIRT1MMP2GNAI3 | |
| SCHEMBL20685656 | 0.81 | MMP2 (0.42) | PAOXSIRT6SIRT1MMP2GNAI3 | |
| SCHEMBL23168318 | 0.81 | MEN1 (0.42) | PAOXSIRT6SIRT1MMP2GNAI3 | |
| SCHEMBL20685654 | 0.81 | MMP2 (0.42) | PAOXSIRT6SIRT1MMP2GNAI3 | |
| SCHEMBL22005704 | 0.81 | MEN1 (0.42) | PAOXSIRT6SIRT1MMP2GNAI3 | |
| SCHEMBL18085365 | 0.80 | PAOX (0.48) | PAOXSIRT6SIRT1KDM4EMAPK1 | |
| SCHEMBL18724552 | 0.79 | ALDH1A1 (0.41) | PAOXSIRT6SIRT1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180459-B2 | Bacterial efflux pump inhibitors | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2021-11-23 | — | — | US | disclosed |
| US-20200140393-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | RUTGERS, THE STATE UNIVERISTY OF NEW JERSEY (US) | 2020-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11180459-B2 | Bacterial efflux pump inhibitors | ABCB11, ABCB1, SLC47A1 | PAOX 1290/4885SIRT6 1748/4885SIRT1 2431/4885 |
| US-20200140393-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | ABCB11, ABCB1, SLC47A1 | PAOX 1290/4885SIRT6 1748/4885SIRT1 2431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.