Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.50 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.50 |
| ▸ | TYK2 | P29597 | 2/20 | 0.50 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | CLK2 | P49760 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13127343 | 0.86 | APP (0.46) | KDM4EALDH1A1POLBGAAAR | |
| SCHEMBL483949 | 0.82 | MAPT (0.39) | KDM4EALDH1A1ARRAB9ANPC1 | |
| SCHEMBL12403530 | 0.82 | MAPT (0.39) | KDM4EALDH1A1ARRAB9ANPC1 | |
| SCHEMBL2452998 | 0.79 | KDM4E (0.62) | KDM4EALDH1A1POLBGAAMAP4K4 | |
| SCHEMBL21974426 | 0.79 | NCF1 (0.61) | KDM4EALDH1A1POLBARRAB9A | |
| SCHEMBL483961 | 0.78 | NPC1 (0.53) | KDM4EALDH1A1ARRAB9ANPC1 | |
| SCHEMBL484168 | 0.72 | AR (0.47) | KDM4EALDH1A1POLBMAP4K4AR | |
| SCHEMBL12403311 | 0.71 | GSK3B (0.47) | KDM4EALDH1A1GAAARRAB9A | |
| SCHEMBL1743192 | 0.70 | NPC1 (0.54) | KDM4EALDH1A1GAAARRAB9A | |
| SCHEMBL2164450 | 0.70 | RAB9A (0.54) | KDM4EALDH1A1GAAMAP4K4CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411057-B1 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | LILLY CO ELI (US) | 2020-05-06 | — | — | EP | disclosed |