Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 2/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6290229 | 0.81 | PSMB5 (0.52) | PSMB5TLR8PDE10ABCHEKCNH2 | |
| SCHEMBL6290855 | 0.76 | TLR8 (0.54) | PSMB5TLR8BCHE | |
| SCHEMBL6289604 | 0.75 | TLR8 (0.55) | PSMB5TLR8BCHE | |
| SCHEMBL11455070 | 0.73 | PDE10A (0.57) | PSMB5TLR8PDE10AKCNH2HRH3 | |
| SCHEMBL8911558 | 0.70 | TLR8 (0.50) | PSMB5TLR8 | |
| SCHEMBL28065707 | 0.68 | TLR8 (0.53) | PSMB5TLR8PDE10AKCNH2HRH3 | |
| SCHEMBL6283828 | 0.68 | NPC1 (0.59) | PSMB5TLR8 | |
| SCHEMBL31593167 | 0.67 | SKP2 (0.55) | PSMB5BCHESKP2 | |
| SCHEMBL1537772 | 0.67 | SKP2 (0.55) | PSMB5BCHESKP2 | |
| SCHEMBL7822732 | 0.67 | NPC1 (0.61) | TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411057-B1 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | LILLY CO ELI (US) | 2020-05-06 | — | — | EP | disclosed |