Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21974818 | 0.89 | MAPT (0.47) | MAPTRAD52ABCG2ABCB1PDE4A | |
| SCHEMBL11885703 | 0.74 | MAPT (0.62) | MAPTKDM4EMAPK1ABCG2PDE4A | |
| SCHEMBL21975143 | 0.74 | MAPT (0.40) | MAPTKDM4EMAPK1LMNARAD52 | |
| SCHEMBL4574977 | 0.74 | MAPK1 (0.51) | MAPTMAPK1PDE4APDE4BPDE4C | |
| SCHEMBL4575030 | 0.73 | KDM4E (0.44) | MAPTKDM4EMAPK1LMNAPDE4A | |
| SCHEMBL4575171 | 0.71 | PDE4A (0.45) | MAPTKDM4EMAPK1LMNAPDE4A | |
| SCHEMBL21975145 | 0.71 | PDE4A (0.41) | MAPTKDM4EMAPK1ABCG2ABCB1 | |
| SCHEMBL9881240 | 0.70 | MAPK1 (0.46) | MAPTKDM4EMAPK1LMNAPDE4A | |
| SCHEMBL4574905 | 0.70 | MAPK1 (0.49) | MAPTKDM4EMAPK1LMNAPDE4A | |
| SCHEMBL9881233 | 0.69 | CYP1A2 (0.61) | MAPTKDM4EMAPK1LMNAABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3647313-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Xiamen University (CN) | 2020-05-06 | — | — | EP | disclosed |