Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 7/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21975145 | 0.83 | PDE4A (0.41) | MAPTKDM4EPDE4APDE4BPDE4C | |
| SCHEMBL21975659 | 0.77 | MAPT (0.37) | MAPTKDM4ELMNAMAPK1POLB | |
| SCHEMBL21975141 | 0.74 | MAPT (0.48) | MAPTHTTKDM4EPDE4APDE4B | |
| SCHEMBL4575030 | 0.73 | KDM4E (0.44) | MAPTHTTKDM4EPDE4APDE4B | |
| SCHEMBL21974967 | 0.72 | PDE4A (0.45) | MAPTHTTKDM4EPDE4APDE4B | |
| SCHEMBL21943478 | 0.71 | KIT (0.61) | MAPTMAPK1RAD52POLB | |
| SCHEMBL21975122 | 0.70 | RAB9A (0.41) | MAPTPDE4APDE4BGAAPOLB | |
| SCHEMBL21974789 | 0.70 | RAB9A (0.41) | MAPTMAPK1GAAPOLBNPSR1 | |
| SCHEMBL4574977 | 0.68 | MAPK1 (0.51) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4743128 | 0.68 | MAPT (0.55) | MAPTHTTKDM4EPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3647313-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Xiamen University (CN) | 2020-05-06 | — | — | EP | disclosed |