Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PRKCI | P41743 | 9/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14103890 | 0.87 | ABCG2 (0.36) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4574977 | 0.86 | MAPK1 (0.51) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL9881240 | 0.80 | MAPK1 (0.46) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL4574905 | 0.79 | MAPK1 (0.49) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL4573992 | 0.77 | MAPK1 (0.44) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL14104446 | 0.77 | TRPA1 (0.41) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL14104444 | 0.76 | PIK3CA (0.42) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL14103803 | 0.74 | CYP1A2 (0.49) | MAPK1MAPTLMNAKDM4EHPGD | |
| SCHEMBL14103885 | 0.73 | TRPA1 (0.38) | MAPK1MAPTKDM4E | |
| SCHEMBL14104083 | 0.73 | L3MBTL1 (0.39) | MAPK1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | claimed |
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |