Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 7/20 | 0.43 |
| ▸ | PRKCI | P41743 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14104446 | 0.92 | TRPA1 (0.41) | MAPK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4574905 | 0.89 | MAPK1 (0.49) | MAPK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14103885 | 0.87 | TRPA1 (0.38) | MAPK1TRPA1L3MBTL1MAPTMET | |
| SCHEMBL14103816 | 0.87 | MTOR (0.40) | MAPK1TRPA1L3MBTL1MAPTMET | |
| SCHEMBL14104083 | 0.87 | L3MBTL1 (0.39) | MAPK1TRPA1L3MBTL1MAPTMET | |
| SCHEMBL14103813 | 0.87 | PIK3CA (0.40) | MAPK1TRPA1L3MBTL1MAPTMET | |
| SCHEMBL14095004 | 0.86 | TRPA1 (0.37) | MAPK1TRPA1L3MBTL1MAPTMET | |
| SCHEMBL14103797 | 0.86 | HTT (0.47) | MAPK1TRPA1L3MBTL1MAPT | |
| SCHEMBL14103756 | 0.86 | TRPA1 (0.41) | MAPK1TRPA1L3MBTL1MAPTMET | |
| SCHEMBL4573992 | 0.86 | MAPK1 (0.44) | MAPK1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | claimed |
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |