Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 14/20 | 0.67 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21976246 | 0.93 | PKLR (0.65) | PKLRAVPR1ATYK2ALDH1A1LMNA | |
| SCHEMBL21976172 | 0.83 | PKLR (0.68) | PKLRAVPR1AALDH1A1LMNACYP46A1 | |
| SCHEMBL21976325 | 0.83 | PKLR (0.67) | PKLRAVPR1AALDH1A1LMNACYP46A1 | |
| SCHEMBL21976119 | 0.83 | PKLR (0.68) | PKLRAVPR1ACYP46A1 | |
| SCHEMBL21976149 | 0.81 | PKLR (0.51) | PKLRAVPR1ATYK2CYP46A1 | |
| SCHEMBL21976611 | 0.81 | PKLR (0.59) | PKLR | |
| SCHEMBL21976171 | 0.81 | PKLR (0.69) | PKLRAVPR1ATYK2CYP46A1 | |
| SCHEMBL21976568 | 0.80 | PKLR (0.70) | PKLRAVPR1ACYP46A1 | |
| SCHEMBL16049744 | 0.80 | PKLR (1.00) | PKLR | |
| SCHEMBL21976639 | 0.77 | PKLR (0.52) | PKLRAVPR1ATYK2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970189-B1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |