Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 13/20 | 0.52 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21976172 | 0.87 | PKLR (0.68) | PKLRAVPR1ALMNAALDH1A1HTT | |
| SCHEMBL21977205 | 0.82 | PKLR (0.63) | PKLRAVPR1A | |
| SCHEMBL16084023 | 0.82 | PKLR (0.78) | PKLRALDH1A1SMN1; SMN2 | |
| SCHEMBL21976325 | 0.81 | PKLR (0.67) | PKLRAVPR1ALMNAALDH1A1HTT | |
| SCHEMBL21976475 | 0.81 | PKLR (0.67) | PKLRLMNAALDH1A1CYP3A4 | |
| SCHEMBL21976584 | 0.80 | PKLR (0.68) | PKLRLMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL21976246 | 0.79 | PKLR (0.65) | PKLRAVPR1ALMNAALDH1A1TYK2 | |
| SCHEMBL21976577 | 0.79 | PKLR (0.68) | PKLRAVPR1AALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL21975976 | 0.77 | PKLR (0.67) | PKLRAVPR1ALMNAALDH1A1TYK2 | |
| SCHEMBL21976119 | 0.77 | PKLR (0.68) | PKLRAVPR1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970189-B1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |