Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 12/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21976172 | 0.89 | PKLR (0.68) | PKLRALDH1A1LMNACYP46A1EPHX2 | |
| SCHEMBL21976577 | 0.86 | PKLR (0.68) | PKLRALDH1A1AVPR1AGAASMN1; SMN2 | |
| SCHEMBL21976246 | 0.83 | PKLR (0.65) | PKLRALDH1A1LMNACYP46A1EPHX2 | |
| SCHEMBL21975976 | 0.83 | PKLR (0.67) | PKLRALDH1A1LMNACYP46A1EPHX2 | |
| SCHEMBL21976475 | 0.83 | PKLR (0.67) | PKLRALDH1A1LMNACYP46A1CHRM2 | |
| SCHEMBL21976584 | 0.82 | PKLR (0.68) | PKLRALDH1A1LMNAMAPK1GAA | |
| SCHEMBL21976639 | 0.81 | PKLR (0.52) | PKLRALDH1A1LMNAAVPR1ASMN1; SMN2 | |
| SCHEMBL16083896 | 0.80 | PKLR (1.00) | PKLR | |
| SCHEMBL21977205 | 0.79 | PKLR (0.63) | PKLREPHX2AVPR1A | |
| SCHEMBL21976121 | 0.78 | PKLR (0.46) | PKLRALDH1A1AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970189-B1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |