Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164257 | 0.82 | MEN1 (0.40) | KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL18087303 | 0.81 | MEN1 (0.31) | KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL14514434 | 0.72 | TP53 (0.36) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL7405510 | 0.71 | KDM4E (0.41) | KMT2AKDM4E | |
| SCHEMBL16049737 | 0.70 | USP2 (0.41) | KDM4E | |
| SCHEMBL11869684 | 0.69 | — | — | |
| SCHEMBL7429095 | 0.69 | KMT2A (0.33) | KMT2AKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL1273304 | 0.69 | OPRM1 (0.36) | KMT2AKDM4E | |
| SCHEMBL27694594 | 0.69 | LMNA (0.32) | — | |
| SCHEMBL15526050 | 0.68 | TSHR (0.34) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970189-B1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |