Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21526626 | 0.78 | KDM4E (0.37) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL9181591 | 0.71 | KDM4E (0.35) | KMT2AKDM4E | |
| SCHEMBL13204894 | 0.71 | GNAI3 (0.36) | KMT2AKDM4E | |
| SCHEMBL25310392 | 0.70 | ALDH1A1 (0.35) | KMT2AKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL21976090 | 0.69 | KMT2A (0.30) | KMT2AKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL1273304 | 0.69 | OPRM1 (0.36) | KMT2AKDM4E | |
| SCHEMBL8125084 | 0.68 | ALDH1A1 (0.46) | KMT2AMEN1ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL7561967 | 0.68 | HTT (0.35) | KMT2AKDM4E | |
| SCHEMBL7392636 | 0.67 | KDM4E (0.41) | KMT2AKDM4E | |
| SCHEMBL1684326 | 0.67 | CYP2C19 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647639-A1 | Heteroarylpiperidines, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-04-12 | — | — | EP | claimed |
| US-5723611-A | Heteroarylpiperidines | SANOFI (FR) | 1998-03-03 | — | — | US | disclosed |
| US-5595994-A | 1-Halopyrazin- and 1-halopyrimidin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1997-01-21 | — | — | US | disclosed |
| US-5502063-A | 1-halopyridin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1996-03-26 | — | — | US | disclosed |
| EP-0647639-A1 | Heteroarylpiperidines, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-04-12 | — | — | EP | disclosed |