Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 16/20 | 0.43 |
| ▸ | FASN | P49327 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21976765 | 0.79 | ALDH1A1 (0.53) | PKLRALDH1A1LMNA | |
| SCHEMBL21976568 | 0.77 | PKLR (0.70) | PKLR | |
| SCHEMBL21976464 | 0.68 | PKLR (0.67) | PKLR | |
| SCHEMBL21976621 | 0.66 | PKLR (0.71) | PKLR | |
| SCHEMBL21976820 | 0.65 | PKLR (0.67) | PKLR | |
| SCHEMBL20192351 | 0.65 | PKLR (0.52) | PKLRALDH1A1LMNAKDM4E | |
| SCHEMBL21976012 | 0.65 | PKLR (0.70) | PKLR | |
| SCHEMBL20192471 | 0.64 | PKM (0.51) | PKLRALDH1A1KDM4EMAPT | |
| SCHEMBL21976601 | 0.64 | PKLR (0.68) | PKLR | |
| SCHEMBL21976228 | 0.64 | PKLR (0.68) | PKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970189-B1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |