Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21979436 | 0.84 | HSD17B10 (0.45) | ALDH1A1MEN1KMT2ALMNAKDM4E | |
| SCHEMBL2103775 | 0.83 | HTT (0.44) | ALDH1A1MEN1KMT2ALMNACYP3A4 | |
| SCHEMBL21979353 | 0.82 | IDO1 (0.36) | ALDH1A1MEN1KMT2ALMNACYP3A4 | |
| SCHEMBL17494979 | 0.82 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2ALMNACYP3A4 | |
| SCHEMBL21979443 | 0.81 | TXNRD1 (0.38) | ALDH1A1MEN1KMT2ALMNAPDE4B | |
| SCHEMBL30189886 | 0.81 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2ALMNAALPL | |
| SCHEMBL30994728 | 0.79 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2AALOX15CYP1A2 | |
| SCHEMBL31345017 | 0.79 | S1PR4 (0.40) | ALDH1A1KMT2ALMNACYP1A2HIF1A | |
| SCHEMBL22691421 | 0.79 | KMT2A (0.38) | ALDH1A1MEN1KMT2ALMNACYP3A4 | |
| SCHEMBL29423582 | 0.79 | KMT2A (0.38) | ALDH1A1MEN1KMT2ALMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11230550-B2 | Macrocyclic HIV-1 protease inhibitors and uses thereof | PURDUE RESEARCH FOUNDATION (US) | 2022-01-25 | — | — | US | disclosed |
| US-20200165264-A1 | MACROCYCLIC HIV-1 PROTEASE INHIBITORS AND USES THEREOF | PURDUE RESEARCH FOUNDATION | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200165264-A1 | MACROCYCLIC HIV-1 PROTEASE INHIBITORS AND USES THEREOF | SERPINB1, CTRL, CTSC | ALDH1A1 1134/4885MEN1 2480/4885KMT2A 3815/4885 |
| US-11230550-B2 | Macrocyclic HIV-1 protease inhibitors and uses thereof | SERPINB1, CTRL, CTSC | ALDH1A1 1134/4885MEN1 2480/4885KMT2A 3815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.