Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CFTR | P13569 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.53 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.47 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.47 |
| ▸ | F3 | P13726 | 1/20 | 0.47 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29937752 | 1.00 | ALDH1A1 (0.55) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 | |
| SCHEMBL362393 | 0.94 | F7 (0.52) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 | |
| SCHEMBL3057993 | 0.92 | MKNK1 (0.50) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 | |
| SCHEMBL4534187 | 0.85 | SMN1; SMN2 (0.58) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 | |
| SCHEMBL2205442 | 0.83 | SLC6A2 (0.54) | ALDH1A1HTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL741751 | 0.82 | MEN1 (0.58) | SMN1; SMN2LMNA | |
| SCHEMBL2815738 | 0.82 | ALDH1A1 (0.49) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 | |
| SCHEMBL14284024 | 0.82 | SMN1; SMN2 (0.55) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 | |
| SCHEMBL10634303 | 0.81 | KCNA5 (0.46) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 | |
| SCHEMBL306372 | 0.81 | F7 (0.53) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107001361-A | Heteroaryl substituted imidazo [1, 2-a ] pyridines and their use | 拜耳医药股份有限公司 | 2017-08-01 | — | — | CN | claimed |
| CN-101203495-B | Benzocycloheptapyridine compounds as inhibitors of receptor tyrosine kinase MET | MERCK SHARP & DOHME | 2013-07-17 | — | — | CN | claimed |
| CN-101203495-A | Benzocycloheptapyridine compounds as inhibitors of receptor tyrosine kinase MET | MERCK & CO INC (US) | 2008-06-18 | — | — | CN | claimed |
| CN-117820236-A | Histone acetyltransferase small molecule inhibitor and preparation method and application thereof | 复旦大学 | 2024-04-05 | — | — | CN | disclosed |
| EP-4077332-A1 | INHIBITORS OF LIN28 AND METHODS OF USE THEREOF | The Regents of the University of California (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021126779-A1 | INHIBITORS OF LIN28 AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-06-24 | — | — | WO | disclosed |
| EP-3510032-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | Incyte Corporation (US) | 2019-07-17 | — | — | EP | disclosed |
| WO-2018049200-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-03-15 | — | — | WO | disclosed |
| CN-103958479-B | Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof | 赛诺菲 | 2017-06-13 | — | — | CN | disclosed |
| CN-103012397-B | Pyrazolo (E)-3-(3-Acetyl-4-hydroxy-5-methoxy-phenyl)-N-(4-hydroxy-1-methyl-3-octyloxy-2-oxo-1,2-dihydro-quinolin-7-yl)-acrylamide, its preparation method and its therapeutic use | 赛诺菲 | 2017-03-01 | — | — | CN | disclosed |
| CN-102731499-B | Lactam compound and the application as medicine thereof | Because of C1-esteraseremmer-N parent corporation (US) | 2016-01-13 | — | — | CN | disclosed |
| CN-101203495-B | Benzocycloheptapyridine compounds as inhibitors of receptor tyrosine kinase MET | MERCK SHARP & DOHME | 2013-07-17 | — | — | CN | disclosed |
| CN-103087078-A | Thienopyridine and furopyridine kinase inhibitors | ABBOTT LAB | 2013-05-08 | — | — | CN | disclosed |
| EP-2519522-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011082270-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE. INC. (US) | 2011-07-07 | — | — | WO | disclosed |
| CN-102007127-A | Furo- and thieno [3,2-c] pyridines | OSI PHARM INC | 2011-04-06 | — | — | CN | disclosed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |
| CN-101203495-A | Benzocycloheptapyridine compounds as inhibitors of receptor tyrosine kinase MET | MERCK & CO INC (US) | 2008-06-18 | — | — | CN | disclosed |
| US-6743794-B2 | MULTIDRUG RESISTANCE PROTEIN; CANCER; 3-(9-CHLORO-3-METHYL-4-OXO-5H-ISOXAZOLO(4,3-C)QUINOLIN-5-YL)) CYCLOHEXYL)-2-PIPERIDYLACETAMIDE | ELI LILLY AND COMPANY | 2004-06-01 | — | — | US | disclosed |