Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CFTR | P13569 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.53 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.47 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.47 |
| ▸ | F3 | P13726 | 1/20 | 0.47 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198036 | 1.00 | ALDH1A1 (0.55) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 | |
| SCHEMBL362393 | 0.94 | F7 (0.52) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 | |
| SCHEMBL3057993 | 0.92 | MKNK1 (0.50) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 | |
| SCHEMBL4534187 | 0.85 | SMN1; SMN2 (0.58) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 | |
| SCHEMBL2205442 | 0.83 | SLC6A2 (0.54) | ALDH1A1HTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL741751 | 0.82 | MEN1 (0.58) | SMN1; SMN2LMNA | |
| SCHEMBL2815738 | 0.82 | ALDH1A1 (0.49) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 | |
| SCHEMBL14284024 | 0.82 | SMN1; SMN2 (0.55) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 | |
| SCHEMBL10634303 | 0.81 | KCNA5 (0.46) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 | |
| SCHEMBL306372 | 0.81 | F7 (0.53) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226203-A1 | PROTEASE INHIBITORS AND METHODS OF USE | THE CLEVELAND CLINIC FOUNDATION (US) | 2022-10-27 | — | — | WO | disclosed |