Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198036 | 0.92 | ALDH1A1 (0.55) | ALDH1A1HTTLMNASMN1; SMN2CFTR | |
| SCHEMBL29937752 | 0.92 | ALDH1A1 (0.55) | ALDH1A1HTTLMNASMN1; SMN2CFTR | |
| SCHEMBL362393 | 0.87 | F7 (0.52) | MKNK1MKNK2ALDH1A1HTTLMNA | |
| SCHEMBL4534187 | 0.79 | SMN1; SMN2 (0.58) | ALDH1A1HTTGAANAMPTSMN1; SMN2 | |
| SCHEMBL2205442 | 0.77 | SLC6A2 (0.54) | ALDH1A1HTTLMNASLC6A2SLC6A4 | |
| SCHEMBL2840256 | 0.77 | HDAC4 (0.60) | MKNK1MKNK2NPC1LMNAGAA | |
| SCHEMBL25279495 | 0.76 | PSEN1 (0.59) | MKNK1MKNK2 | |
| SCHEMBL741751 | 0.76 | MEN1 (0.58) | LMNASMN1; SMN2 | |
| SCHEMBL2815738 | 0.76 | ALDH1A1 (0.49) | ALDH1A1HTTLMNASMN1; SMN2CFTR | |
| SCHEMBL14284024 | 0.76 | SMN1; SMN2 (0.55) | ALDH1A1HTTSMN1; SMN2CFTRSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781591-B2 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC (US) | 2010-08-24 | — | — | US | disclosed |
| US-20070287708-A1 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287708-A1 | Substituted 3-cyanopyridines as protein kinase inhibitors | CNKSR1, MAP3K1, MAP3K7 | MKNK1 209/4885MKNK2 199/4885ALDH1A1 2828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.