Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 2/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26070115 | 0.80 | RAB9A (0.56) | HPGDTNKSPARP1TNKS2PDE2A | |
| SCHEMBL4822785 | 0.77 | GSK3B (0.84) | MAPTGAAHPGDGSK3BPOLB | |
| SCHEMBL7504407 | 0.75 | GAA (1.00) | MAPTGAAHPGDGSK3BPOLB | |
| SCHEMBL14508422 | 0.75 | MAPT (0.64) | MAPTGAAHPGDGSK3BPOLB | |
| SCHEMBL29310490 | 0.74 | GSK3B (0.79) | MAPTGAAHPGDGSK3BPOLB | |
| SCHEMBL8678958 | 0.73 | MAPT (0.57) | MAPTGAAHPGDGSK3BPOLB | |
| SCHEMBL474098 | 0.73 | BTK (0.41) | MAPTGAAHPGDPOLBKMT2A | |
| SCHEMBL18035933 | 0.72 | PDE2A (0.60) | MAPTGAAHPGDGSK3BPDE2A | |
| SCHEMBL8678449 | 0.71 | HPGD (1.00) | MAPTGAAHPGDGSK3BPOLB | |
| SCHEMBL10490276 | 0.71 | POLB (0.66) | MAPTGAAHPGDGSK3BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3087060-B1 | PYRIMIDONE CARBOXAMIDE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2020-05-13 | — | — | EP | disclosed |