Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 15/20 | 0.54 |
| ▸ | DRD4 | P21917 | 6/20 | 0.54 |
| ▸ | DRD3 | P35462 | 11/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9567518 | 0.82 | DRD2 (0.66) | DRD2DRD4DRD3HTR1AADRA1D | |
| SCHEMBL2097964 | 0.82 | HTR1A (0.53) | DRD2DRD4DRD3HTR1AADRA1D | |
| SCHEMBL2094204 | 0.81 | HTR1A (0.52) | DRD2DRD4DRD3HTR1AADRA1D | |
| SCHEMBL8828778 | 0.80 | DRD2 (0.53) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL2091611 | 0.80 | DRD2 (0.52) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL7605693 | 0.80 | HTR1A (0.48) | DRD2DRD4DRD3HTR1AADRA1D | |
| SCHEMBL2088381 | 0.77 | DRD2 (0.50) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL7733978 | 0.77 | DRD2 (0.50) | DRD2DRD4DRD3HTR1AADRA1D | |
| SCHEMBL7733968 | 0.77 | DRD2 (0.50) | DRD2DRD4DRD3HTR1AADRA1D | |
| SCHEMBL6935595 | 0.74 | HTR1A (0.58) | DRD2DRD4DRD3HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350182-B1 | NOVEL PIPERAZINE AND PIPERIDINE DERIVATIVES, THEIR SYNTHESIS AND USE THEREOF IN INHIBITING VDAC OLIGOMERIZATION, APOPTOSIS AND MITOCHONDRIA DYSFUNCTION | NAT INST BIOTECHNOLOGY NEGEV LTD (IL) | 2020-06-03 | — | — | EP | disclosed |