Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.59 |
| ▸ | HRH2 | P25021 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | DRD3 | P35462 | 2/20 | 0.59 |
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | TEK | Q02763 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 4/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | BCL2 | P10415 | 5/20 | 0.48 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5686168 | 0.99 | HRH1 (0.60) | HRH1HRH2HTR2ADRD3HTR2B | |
| Hydrochloric Acid SCHEMBL219199 | 0.99 | HRH1 (0.60) | HRH1HRH2HTR2ADRD3HTR2B | |
| SCHEMBL2058761 | 0.98 | HRH1 (0.57) | HRH1HRH2HTR2ADRD3HTR2B | |
| Hydrochloric Acid SCHEMBL10930701 | 0.97 | HRH1 (0.58) | HRH1HRH2HTR2ADRD3HTR2B | |
| SCHEMBL1569359 | 0.90 | HTR7 (0.50) | HRH1HRH2HTR2ADRD3HTR2B | |
| Potassium Ion SCHEMBL2058535 | 0.89 | HTR7 (0.49) | HRH1HRH2HTR2ADRD3HTR2B | |
| SCHEMBL2058741 | 0.89 | HRH3 (0.49) | HRH1HRH2HTR2ADRD3HTR2B | |
| SCHEMBL5182319 | 0.88 | HTR7 (0.53) | HRH1HRH2HTR2ADRD3HTR2B | |
| SCHEMBL7628259 | 0.88 | HTR7 (0.48) | HRH1HRH2HTR2ADRD3HTR2B | |
| Water SCHEMBL10930920 | 0.88 | HRH3 (0.48) | HRH1HRH2HTR2ADRD3HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 247 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8350031-B2 | Processes for the synthesis of levocetirizine and intermediates for use therein | CIPLA LIMITED (IN) | 2013-01-08 | — | — | US | claimed |
| EP-1734918-B1 | PHARMACEUTICAL COMPOSITION FOR TREATING HAIR LOSS AND BENIGN PROSTATIC HYPERPLASIA | LEE EUN-JOO (KR) | 2012-08-01 | — | — | EP | claimed |
| US-8088775-B2 | Pharmaceutical composition for treating hair loss | KIM, SOLOMON L. | 2012-01-03 | — | — | US | claimed |
| US-20110184174-A1 | Processes for the Synthesis of Levocetirizine and Intermediates for Use Therein | CIPLA LIMITED (IN) | 2011-07-28 | — | — | US | claimed |
| US-7968549-B2 | Diarylmethylpiperazines as therapeutic agents for viral myocarditis | MATSUMORI AKIRA | 2011-06-28 | — | — | US | claimed |
| EP-2307392-A2 | PROCESSES FOR THE SYNTHESIS OF LEVOCETIRIZINE AND INTERMEDIATES FOR USE THEREIN | Cipla Limited (IN) | 2011-04-13 | — | — | EP | claimed |
| US-20100222364-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING HAIR LOSS AND BENIGN PROSTATIC HYPERPLASIA | KIM, SOLOMON L. | 2010-09-02 | — | — | US | claimed |
| WO-2009147389-A2 | PROCESSES FOR THE SYNTHESIS OF LEVOCETIRIZINE AND INTERMEDIATES FOR USE THEREIN | CIPLA LIMITED (IN) | 2009-12-10 | — | — | WO | claimed |
| US-20080287459-A1 | Pharmaceutical Composition for Treating Hair Loss and Benign Prostatic Hyperplasia | LEE EUN-JOO | 2008-11-20 | — | — | US | claimed |
| US-20070142400-A1 | For treatment of allergies; antihistamines | COSSEMENT ERIC | 2007-06-21 | — | — | US | claimed |
| US-20030105113-A1 | Enantiomers of 1-[ (4-chlorophenyl) phenylmethyl ] -4-[ (4-methylphenyl) sulfonyl ] piperazine | COSSEMENT ERIC (BE) | 2003-06-05 | — | — | US | claimed |
| US-6469009-B1 | MIXTURE CONSISTING ESSENTIALLY OF PSEUDOEPHEDRINE AND COMPOUND SELECTED FROM 2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)-ACETIC ACID OR AMIDE DERIVATIVES, THEIR INDIVIDUAL OPTICAL ISOMERS OR PHARMACEUTICALLY ACCEPTABLE SALTS | UCB, S.A. (BE) | 2002-10-22 | — | — | US | claimed |
| US-6413970-B1 | Pharmaceutical composition for treating viral diseases | UCB S.A. (BE) | 2002-07-02 | — | — | US | claimed |
| EP-0927173-B1 | SUBSTITUTED [2-(1-PIPERAZINYL)ETHOXY]METHYL | UCB SA (BE) | 2002-06-12 | — | — | EP | claimed |
| US-20010020023-A1 | Pharmaceutical compositions for the treatment of rhinitis | UCB PHARMA, S.A. (BE) | 2001-09-06 | — | — | US | claimed |
| US-6255487-B1 | PREPARING 2-(2-(4-((4-CHLOROPHENYL)PHENYLMETHYL)-1-PIPER-AZINYL)ETHOXY)ACETIC ACID VIA REACTING SUBSTITUTED (2-((1-PIPERAZINYL)ETHOXY)METHYL COMPOUND WITH A DIPHENYLMETHYL HALIDE, THEN HYDROLYZING IN ALCOHOLIC MEDIUM WITH ACID/BASE | UCB, S.A. (BE) | 2001-07-03 | — | — | US | claimed |
| EP-0955295-A1 | Therapeutically active levorotatory and dextrorotatory 1-((4-chlorophenyl)phenylmethyl) piperazines | UCB, S.A. (BE) | 1999-11-10 | — | — | EP | claimed |
| EP-0617028-A1 | Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulfonyl piperazine | U C B, S.A. (BE) | 1994-09-28 | — | — | EP | claimed |
| US-4525358-A | ANTIHISTAMINES, ANTIALLERGENS, ANTISPASMODICS, BRONCHODILATORS | UCB PHARMACEUTICALS, INC. (US) | 1985-06-25 | — | — | US | claimed |
| EP-0058146-B1 | 2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)-ACETIC ACIDS AND THEIR AMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | U C B, S.A. (BE) | 1984-06-27 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110184174-A1 | Processes for the Synthesis of Levocetirizine and Intermediates for Use Therein | CYP3A5, CYP4A11, IL5 | HRH1 82/4885HRH2 148/4885HTR2A 382/4885 |
| US-20030105113-A1 | Enantiomers of 1-[ (4-chlorophenyl) phenylmethyl ] -4-[ (4-methylphenyl) sulfonyl ] piperazine | RPLP1, QDPR, PRLHR | HRH1 135/4885HRH2 224/4885HTR2A 30/4885 |
| US-20070142400-A1 | For treatment of allergies; antihistamines | HRH2, HRH1, HRH4 | HRH1 2/4885HRH2 1/4885HTR2A 140/4885 |
| US-20080287459-A1 | Pharmaceutical Composition for Treating Hair Loss and Benign Prostatic Hyperplasia | SHBG, CYP17A1, NR5A1 | HRH1 3049/4885HRH2 3256/4885HTR2A 1417/4885 |
| US-20010020023-A1 | Pharmaceutical compositions for the treatment of rhinitis | HRH4, HRH2, HRH1 | HRH1 3/4885HRH2 2/4885HTR2A 180/4885 |
| US-20100222364-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING HAIR LOSS AND BENIGN PROSTATIC HYPERPLASIA | BPHL, ACP3, PSAP | HRH1 2676/4885HRH2 3228/4885HTR2A 2102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.