Sugi Predict

Sugi Predict / Compounds / SCHEMBL21989355

SCHEMBL21989355

SCHEMBL21989355

CC1(C)C(=O)Nc2cc(B3OC(C)(C)C(C)(C)O3)cnc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GSK3A P49840 1/20 0.38
▸ GSK3B P49841 1/20 0.38
▸ DGAT1 O75907 2/20 0.36
▸ MAPK14 Q16539 1/20 0.35
▸ PDGFRB P09619 2/20 0.35
▸ KDR P35968 2/20 0.35
▸ AAK1 Q2M2I8 1/20 0.33
▸ ALPL P05186 1/20 0.32
▸ LPL P06858 4/20 0.32
▸ LIPG Q9Y5X9 4/20 0.32
▸ FFAR1 O14842 1/20 0.31
▸ CA1 P00915 2/20 0.31
▸ CA2 P00918 2/20 0.31
▸ CA9 Q16790 2/20 0.31
▸ CA12 O43570 1/20 0.31
▸ CA3 P07451 1/20 0.31
▸ CA4 P22748 1/20 0.31
▸ CA6 P23280 1/20 0.31
▸ CA5A P35218 1/20 0.31
▸ CA7 P43166 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21989303 0.86 GSK3A (0.39) GSK3AGSK3BDGAT1PDGFRBKDR
SCHEMBL15779501 0.73 GSK3A (0.36) GSK3AGSK3BDGAT1PDGFRBKDR
SCHEMBL30016605 0.73 PDK2 (0.46) MAPK14LPLLIPGCA1CA2
SCHEMBL1222481 0.73 PDK2 (0.46) MAPK14LPLLIPGCA1CA2
SCHEMBL24496572 0.73 MAPK14 (0.43) MAPK14MAP3K11PDK2PDK4
SCHEMBL16426571 0.71 GSK3A (0.34) GSK3AGSK3BDGAT1PDGFRBKDR
SCHEMBL1233902 0.71 HTR6 (0.40) GSK3AGSK3BMAPK14PDGFRBKDR
SCHEMBL29391023 0.71 HTR6 (0.40) GSK3AGSK3BMAPK14PDGFRBKDR
SCHEMBL391545 0.70 NR3C2 (0.42) GSK3AGSK3BDGAT1PDGFRBKDR
SCHEMBL31116974 0.70 PGR (0.47) LPLLIPGPDK2PDK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4371987-B9 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS GILEAD SCIENCES INC (US) 2025-11-26 — — EP disclosed
EP-4371987-B1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS GILEAD SCIENCES INC (US) 2025-09-17 — — EP disclosed
US-12258346-B2 Substituted 6-azabenzimidazole compounds GILEAD SCIENCES, INC. (US) 2025-03-25 — — US disclosed
US-20240287061-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS GILEAD SCIENCES, INC. 2024-08-29 — — US disclosed
CN-113227089-B Substituted 6-azabenzimidazole compounds as HPK1 inhibitors 吉利德科学公司 2024-07-05 — — CN disclosed
EP-4371987-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS Gilead Sciences, Inc. (US) 2024-05-22 — — EP disclosed
US-11925631-B2 Substituted 6-azabenzimidazole compounds GILEAD SCIENCES, INC. (US) 2024-03-12 — — US disclosed
US-11897878-B2 Substituted 6-azabenzimidazole compounds GILEAD SCIENCES, INC. (US) 2024-02-13 — — US disclosed
EP-3873903-B1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS GILEAD SCIENCES INC (US) 2024-01-24 — — EP disclosed
EP-3873903-B1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS GILEAD SCIENCES INC (US) 2024-01-24 — — EP disclosed
EP-3873903-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS GILEAD SCIENCES, INC. (US) 2021-09-08 — — EP disclosed
EP-3873608-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS HAVING HPK1 INHIBITORY ACTIVITY GILEAD SCIENCES, INC. (US) 2021-09-08 — — EP disclosed
CN-113227089-A Substituted 6-azabenzimidazole compounds as HPK1 inhibitors 吉利德科学公司 2021-08-06 — — CN disclosed
US-11071730-B2 Substituted 6-azabenzimidazole compounds GILEAD SCIENCES, INC. (US) 2021-07-27 — — US disclosed
US-11071730-B2 Substituted 6-azabenzimidazole compounds GILEAD SCIENCES, INC. (US) 2021-07-27 — — US disclosed
CN-112969505-A Substituted 6-azabenzimidazole compounds having HPK1 inhibiting activity 吉利德科学公司 2021-06-15 — — CN disclosed
US-20210115037-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS GILEAD SCIENCES, INC. 2021-04-22 — — US disclosed
US-20210115037-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS GILEAD SCIENCES, INC. 2021-04-22 — — US disclosed
US-20200171020-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS GILEAD SCIENCES, INC. 2020-06-04 — — US disclosed
US-20200171020-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS GILEAD SCIENCES, INC. 2020-06-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240287061-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS CDK6, HIPK1, DCK GSK3A 346/4885GSK3B 275/4885DGAT1 2235/4885
US-12258346-B2 Substituted 6-azabenzimidazole compounds CDK6, HIPK1, DCK GSK3A 346/4885GSK3B 275/4885DGAT1 2235/4885
US-11925631-B2 Substituted 6-azabenzimidazole compounds CDK6, HIPK1, DCK GSK3A 346/4885GSK3B 275/4885DGAT1 2235/4885
US-20210115037-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS CDK6, HIPK1, DCK GSK3A 346/4885GSK3B 275/4885DGAT1 2235/4885
US-11071730-B2 Substituted 6-azabenzimidazole compounds CDK6, HIPK1, DCK GSK3A 346/4885GSK3B 275/4885DGAT1 2235/4885
US-20200171020-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS CDK6, HIPK1, DCK GSK3A 346/4885GSK3B 275/4885DGAT1 2235/4885
US-11897878-B2 Substituted 6-azabenzimidazole compounds CDK6, HIPK1, DCK GSK3A 346/4885GSK3B 275/4885DGAT1 2235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.