Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL21990689 | 0.91 | TDP1 (0.39) | CA1CA2NFKB1CA4TDP1 | |
| SCHEMBL15000 | 0.89 | TDP1 (0.44) | TDP1TSHRSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL29361804 | 0.89 | TDP1 (0.44) | TDP1TSHRSMN1; SMN2HTTALDH1A1 | |
| Benzene SCHEMBL11665509 | 0.87 | TDP1 (0.41) | TDP1TSHRSMN1; SMN2HTTMAPT | |
| SCHEMBL332205 | 0.87 | TDP1 (0.43) | TDP1TSHRSMN1; SMN2HTTALDH1A1 | |
| Formaldehyde SCHEMBL10338469 | 0.87 | TDP1 (0.43) | TDP1TSHRSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL6131308 | 0.87 | TDP1 (0.43) | TDP1TSHRSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL1888655 | 0.87 | TDP1 (0.43) | TDP1TSHRSMN1; SMN2HTTALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL142076 | 0.87 | TDP1 (0.43) | TDP1TSHRSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL1806020 | 0.87 | TDP1 (0.43) | TDP1TSHRSMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11459410-B2 | High-purity amphipathic arylsulfonic acid amine salt vinyl monomer and copolymer thereof | TOSOH FINECHEM CORPORATION (JP) | 2022-10-04 | — | — | US | disclosed |
| EP-3666753-A1 | HIGH-PURITY AMPHIPATHIC ARYLSULFONIC ACID AMINE SALT VINYL MONOMER AND COPOLYMER THEREOF | Tosoh Finechem Corporation (JP) | 2020-06-17 | — | — | EP | disclosed |
| US-20200172643-A1 | HIGH-PURITY AMPHIPATHIC ARYLSULFONIC ACID AMINE SALT VINYL MONOMER AND COPOLYMER THEREOF | TOSOH FINECHEM CORPORATION (JP) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11459410-B2 | High-purity amphipathic arylsulfonic acid amine salt vinyl monomer and copolymer thereof | SLC7A1, ARSA, STS | CA1 3904/4885CA2 2972/4885NFKB1 3062/4885 |
| US-20200172643-A1 | HIGH-PURITY AMPHIPATHIC ARYLSULFONIC ACID AMINE SALT VINYL MONOMER AND COPOLYMER THEREOF | SLC7A1, ARSA, STS | CA1 3904/4885CA2 2972/4885NFKB1 3062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.