Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | MST1R | Q04912 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 3/20 | 0.35 |
| ▸ | SDCBP | O00560 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2199646 | 0.96 | DGAT1 (0.36) | MAPK1DGAT1JAK2NTRK1MET | |
| SCHEMBL2179478 | 0.89 | ABCB1 (0.44) | GSK3BABCB1 | |
| SCHEMBL2198725 | 0.88 | JAK2 (0.40) | MAPK1DGAT1JAK2NTRK1MET | |
| SCHEMBL2195168 | 0.87 | DGAT1 (0.36) | MAPK1DGAT1SDCBPSDC2BRD4 | |
| SCHEMBL13718913 | 0.86 | ABCB1 (0.43) | GSK3BABCB1 | |
| SCHEMBL2179848 | 0.86 | ABCB1 (0.43) | GSK3BABCB1 | |
| SCHEMBL2196753 | 0.84 | JAK2 (0.38) | DGAT1JAK2NTRK1METFGFR1 | |
| SCHEMBL2202230 | 0.84 | JAK2 (0.38) | DGAT1JAK2NTRK1METFGFR1 | |
| SCHEMBL2195751 | 0.84 | TDP2 (0.40) | MAPK1TDP2ADAM17SDCBPSDC2 | |
| SCHEMBL2197327 | 0.80 | RARB (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |