Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31098407 | 0.89 | LMNA (0.43) | LMNAPOLBSMN1; SMN2NAMPTNR1H2 | |
| SCHEMBL29689830 | 0.89 | LMNA (0.43) | LMNAPOLBSMN1; SMN2NAMPTNR1H2 | |
| SCHEMBL31549307 | 0.81 | POLB (0.49) | LMNAPOLBSMN1; SMN2NR1H2HRH2 | |
| SCHEMBL2265266 | 0.80 | NR1H2 (0.65) | LMNAPOLBSMN1; SMN2NAMPTNR1H2 | |
| SCHEMBL19722672 | 0.76 | NAMPT (0.41) | NAMPTNR1H2PSEN1PSEN2APH1B | |
| SCHEMBL29627948 | 0.74 | LMNA (0.43) | LMNAPOLBSMN1; SMN2NAMPTNR1H2 | |
| SCHEMBL30939083 | 0.73 | SMN1; SMN2 (0.42) | LMNAPOLBSMN1; SMN2NAMPTHRH2 | |
| SCHEMBL21995408 | 0.73 | LMNA (0.42) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL1396142 | 0.72 | LMNA (0.56) | LMNAPOLBSMN1; SMN2NR1H2HRH2 | |
| SCHEMBL29627986 | 0.72 | P2RY12 (0.42) | LMNAPOLBSMN1; SMN2HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3887371-A1 | ARYL COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | F. Hoffmann-La Roche AG (CH) | 2021-10-06 | — | — | EP | disclosed |
| WO-2020109191-A1 | ARYL COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-04 | — | — | WO | disclosed |