Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.35 |
| ▸ | CDK2 | P24941 | 6/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30044501 | 0.75 | MAPK1 (0.43) | SMN1; SMN2HRH2HRH1MAPK1 | |
| SCHEMBL34473620 | 0.74 | LMNA (0.42) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL21994935 | 0.73 | LMNA (0.43) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL21995304 | 0.73 | CCNA2 (0.39) | CCNA2CDK2CCNA1AURKAKMT2A | |
| SCHEMBL12811458 | 0.72 | LMNA (0.40) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL1396142 | 0.71 | LMNA (0.56) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL30054187 | 0.70 | LMNA (0.54) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL29574115 | 0.69 | LMNA (0.42) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL29689830 | 0.68 | LMNA (0.43) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL31549252 | 0.67 | LMNA (0.48) | LMNAPOLBSMN1; SMN2HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3887371-A1 | ARYL COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | F. Hoffmann-La Roche AG (CH) | 2021-10-06 | — | — | EP | disclosed |
| WO-2020109191-A1 | ARYL COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-04 | — | — | WO | disclosed |