Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.51 |
| ▸ | BRD3 | Q15059 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CDC42 | P60953 | 1/20 | 0.43 |
| ▸ | RB1 | P06400 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21996119 | 0.87 | RB1 (0.60) | CYP2D6KCNH2SIRT1BRD3MAPT | |
| SCHEMBL21998621 | 0.84 | CYP2D6 (0.53) | CYP2D6KCNH2SIRT1BRD3MAPT | |
| SCHEMBL21998622 | 0.83 | GAA (0.67) | CYP2D6KCNH2SIRT1BRD3MAPT | |
| SCHEMBL21996157 | 0.83 | CYP2D6 (0.79) | CYP2D6KCNH2BRD3MAPTALOX15 | |
| SCHEMBL21994103 | 0.81 | CDC42 (0.55) | CYP2D6KCNH2SIRT1BRD3GAA | |
| SCHEMBL15278222 | 0.77 | CYP2D6 (0.55) | CYP2D6KCNH2SIRT1BRD3MAPT | |
| SCHEMBL16433472 | 0.77 | SIRT1 (0.63) | CYP2D6KCNH2SIRT1BRD3MAPT | |
| SCHEMBL21156055 | 0.76 | CYP2D6 (0.78) | CYP2D6KCNH2SIRT1BRD3MAPT | |
| SCHEMBL25293518 | 0.76 | CYP2D6 (0.72) | CYP2D6KCNH2BRD3MAPTALOX15 | |
| SCHEMBL30454869 | 0.76 | CYP2D6 (0.72) | CYP2D6KCNH2BRD3MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200147069-A1 | Compounds for The Reduction of The Deleterious Activity of Extended Nucleotide Repeat Containing Genes | THE BOARD OF TRUSTEES OF LELAND STANFORD JUNIOR UNIVERSITY | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200147069-A1 | Compounds for The Reduction of The Deleterious Activity of Extended Nucleotide Repeat Containing Genes | NSUN2, RNMT, RRM2B | CYP2D6 3849/4885KCNH2 4403/4885SIRT1 1148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.