⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22683517 | 0.77 | KDM4C (0.33) | — | |
| SCHEMBL18572155 | 0.70 | KDM4C (0.33) | — | |
| SCHEMBL22002023 | 0.69 | CA12 (0.33) | — | |
| SCHEMBL10585694 | 0.64 | — | — | |
| SCHEMBL12324803 | 0.62 | — | — | |
| SCHEMBL18572161 | 0.60 | — | — | |
| SCHEMBL25159163 | 0.59 | CTSD (0.32) | — | |
| SCHEMBL24061467 | 0.58 | CHRNB2 (0.31) | — | |
| SCHEMBL28282124 | 0.58 | — | — | |
| SCHEMBL15392194 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10653711-B2 | 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2020-05-19 | — | — | US | disclosed |