Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.30 |
| ▸ | SCD | O00767 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14780274 | 0.78 | CYP11B1 (0.44) | CYP11B2CYP11B1 | |
| SCHEMBL17247603 | 0.68 | MKNK1 (0.52) | CYP11B2CYP11B1DYRK1ACYP2A6FYN | |
| SCHEMBL31259931 | 0.67 | CYP11B1 (0.44) | CYP11B2CYP11B1 | |
| SCHEMBL14778670 | 0.67 | CYP11B1 (0.44) | CYP11B2CYP11B1 | |
| SCHEMBL14778968 | 0.67 | CYP11B1 (0.47) | CYP11B2CYP11B1 | |
| SCHEMBL14816641 | 0.66 | PRMT5 (0.38) | CYP11B2CYP11B1DYRK1ACYP2A6KDM5B | |
| SCHEMBL22004689 | 0.64 | CYP11B1 (0.42) | CYP11B2CYP11B1HCRTR1HCRTR2 | |
| SCHEMBL21338267 | 0.63 | CYP11B1 (0.69) | CYP11B2CYP11B1 | |
| SCHEMBL28198655 | 0.62 | CYP11B2 (0.41) | CYP11B2CYP11B1DYRK1ACYP2A6FYN | |
| SCHEMBL22005290 | 0.62 | CYP11B2 (0.51) | CYP11B2CYP11B1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3653618-A1 | NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2020-05-20 | — | — | EP | disclosed |