Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 12/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 10/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14816637 | 0.88 | CYP11B2 (0.38) | CYP11B2CYP11B1CYP1A2CYP2C9TBXAS1 | |
| SCHEMBL14778933 | 0.77 | CRBN (0.48) | CYP11B2CYP11B1CYP1A2CYP19A1MAPT | |
| SCHEMBL31259930 | 0.77 | CYP11B1 (0.59) | CYP11B2CYP11B1CYP1A2CYP2C9TBXAS1 | |
| SCHEMBL14780112 | 0.77 | CYP11B1 (0.59) | CYP11B2CYP11B1CYP1A2CYP2C9TBXAS1 | |
| SCHEMBL14780274 | 0.74 | CYP11B1 (0.44) | CYP11B2CYP11B1CYP1A2CYP19A1 | |
| SCHEMBL1396656 | 0.68 | KIF11 (0.58) | MAPTALDH1A1POLBHTTSMN1; SMN2 | |
| SCHEMBL22004573 | 0.66 | CYP11B2 (0.39) | CYP11B2CYP11B1DYRK1AKDM5BCYP2A6 | |
| SCHEMBL14778457 | 0.65 | CYP11B1 (0.62) | PRMT5WDR77CYP11B2CYP11B1CYP1A2 | |
| SCHEMBL19376194 | 0.64 | MAOA (0.51) | CYP11B2CYP11B1CYP1A2CYP2C9TBXAS1 | |
| SCHEMBL25211244 | 0.63 | NPC1 (0.40) | CYP11B2CYP11B1CYP1A2CYP2C9TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013037779-A1 | NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-21 | — | — | WO | disclosed |