Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | AHR | P35869 | 3/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11985801 | 0.80 | BRD4 (0.41) | HPGDALDH1A1BRD4CYP3A4MAPK1 | |
| SCHEMBL21060120 | 0.77 | TDP1 (0.48) | ALDH1A1CSNK2A1BRD4AHRCYP2A6 | |
| SCHEMBL30316924 | 0.77 | CSNK2A1 (0.39) | HPGDALDH1A1CSNK2A1AHRCYP2A6 | |
| SCHEMBL30675146 | 0.77 | TDP1 (0.48) | ALDH1A1CSNK2A1BRD4AHRCYP2A6 | |
| SCHEMBL19701194 | 0.77 | CSNK2A1 (0.43) | HPGDALDH1A1CSNK2A1BRD4AHR | |
| SCHEMBL22732074 | 0.77 | CSNK2A1 (0.47) | ALDH1A1CSNK2A1AHRCYP2A6NR4A2 | |
| SCHEMBL30317205 | 0.76 | ALDH1A1 (0.33) | HPGDALDH1A1APOBEC3GCSNK2A1BRD4 | |
| SCHEMBL30317206 | 0.76 | ALDH1A1 (0.33) | HPGDALDH1A1APOBEC3GCSNK2A1BRD4 | |
| SCHEMBL21672437 | 0.76 | BRD4 (0.38) | HPGDALDH1A1BRD4CYP2A6CYP3A4 | |
| SCHEMBL21743424 | 0.74 | BRD4 (0.37) | HPGDALDH1A1LMNABRD4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200157092-A1 | [1,2,4]-TRIAZOLO [1,5-A]-PYRIMIDINYL DERIVATIVES SUBSTITUTED WITH PIPERIDINE, MORPHOLINE OR PIPERAZINE AS OGA INHIBITORS | Janssen Pharmaceutlca NV (BE) | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157092-A1 | [1,2,4]-TRIAZOLO [1,5-A]-PYRIMIDINYL DERIVATIVES SUBSTITUTED WITH PIPERIDINE, MORPHOLINE OR PIPERAZINE AS OGA INHIBITORS | OGA, PSEN1, PSEN2 | HPGD 3346/4885ALDH1A1 2667/4885LMNA 777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.