Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.32 |
| ▸ | MYC | P01106 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30317206 | 1.00 | ALDH1A1 (0.33) | ALDH1A1KDM4EGAAHPGDKMT2A | |
| SCHEMBL22004970 | 0.76 | HPGD (0.43) | ALDH1A1KDM4EHPGDCSNK2A1APOBEC3G | |
| SCHEMBL22732074 | 0.69 | CSNK2A1 (0.47) | ALDH1A1CSNK2A1AHRCYP2A6NR4A2 | |
| SCHEMBL30316924 | 0.69 | CSNK2A1 (0.39) | ALDH1A1KDM4EGAAHPGDKMT2A | |
| SCHEMBL21060120 | 0.69 | TDP1 (0.48) | ALDH1A1KDM4EKMT2ACSNK2A1CYP3A4 | |
| SCHEMBL30675146 | 0.69 | TDP1 (0.48) | ALDH1A1KDM4EKMT2ACSNK2A1CYP3A4 | |
| SCHEMBL15410811 | 0.66 | IMPDH2 (0.40) | CSNK2A1AHRCYP2A6NR4A2MAPK1 | |
| SCHEMBL11985801 | 0.65 | BRD4 (0.41) | ALDH1A1KDM4EHPGDKMT2AHSD17B10 | |
| SCHEMBL20552180 | 0.64 | MMP2 (0.40) | ALDH1A1KDM4EHPGDNR4A2AMY1A | |
| SCHEMBL8523412 | 0.62 | KDM4E (0.55) | ALDH1A1KDM4EKMT2AHSD17B10MYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368153-A1 | Aminopyridine-based MTA-Cooperative PRMT5 Inhibitors | Mirati Therapeutics, Inc. | 2024-11-07 | — | — | US | disclosed |
| WO-2023278564-A1 | AMINOPYRIDINE-BASED MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240368153-A1 | Aminopyridine-based MTA-Cooperative PRMT5 Inhibitors | PRMT5, PRMT1, PRMT3 | ALDH1A1 3597/4885KDM4E 97/4885GAA 3475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.