Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | POLA1 | P09884 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.39 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | ADH1B | P00325 | 1/20 | 0.38 |
| ▸ | ADH1C | P00326 | 1/20 | 0.38 |
| ▸ | ADH1A | P07327 | 1/20 | 0.38 |
| ▸ | ADH4 | P08319 | 1/20 | 0.38 |
| ▸ | ADH7 | P40394 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18723159 | 1.00 | ZDHHC7 (0.47) | ZDHHC7HCAR2KEAP1NFE2L2POLB | |
| SCHEMBL22005512 | 1.00 | ZDHHC7 (0.47) | ZDHHC7HCAR2KEAP1NFE2L2POLB | |
| SCHEMBL31578979 | 0.98 | ZDHHC7 (0.46) | ZDHHC7HCAR2KEAP1NFE2L2POLB | |
| SCHEMBL26047189 | 0.84 | ZDHHC7 (0.50) | ZDHHC7HCAR2KEAP1NFE2L2POLB | |
| SCHEMBL30914719 | 0.84 | HCAR2 (0.45) | ZDHHC7HCAR2GPR84FFAR1MAPT | |
| SCHEMBL21694608 | 0.84 | HCAR2 (0.45) | ZDHHC7HCAR2GPR84FFAR1MAPT | |
| SCHEMBL18723218 | 0.84 | HCAR2 (0.45) | ZDHHC7HCAR2GPR84FFAR1MAPT | |
| SCHEMBL25808263 | 0.83 | HCAR2 (0.44) | ZDHHC7HCAR2GPR84FFAR1MAPT | |
| SCHEMBL22627138 | 0.82 | HCAR2 (0.46) | ZDHHC7HCAR2GPR84FFAR1MAPT | |
| SCHEMBL22465645 | 0.82 | HCAR2 (0.46) | ZDHHC7HCAR2GPR84FFAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11129819-B2 | Fumarate analogs and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2021-09-28 | — | — | US | disclosed |
| US-20200155531-A1 | Fumarate Analogs and Uses Thereof | MIDCAP FINANCIAL TRUST | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155531-A1 | Fumarate Analogs and Uses Thereof | FH, GLS, FPGS | ZDHHC7 325/4885HCAR2 737/4885KEAP1 344/4885 |
| US-11129819-B2 | Fumarate analogs and uses thereof | FH, GLS, FPGS | ZDHHC7 325/4885HCAR2 737/4885KEAP1 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.