Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.64 |
| ▸ | ESRRA | P11474 | 3/20 | 0.64 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.59 |
| ▸ | MGAM | O43451 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | SI | P14410 | 1/20 | 0.56 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2697203 | 0.92 | ESRRA (0.75) | PDE4BMEN1KMT2AESRRAFOXM1 | |
| SCHEMBL2697205 | 0.92 | ESRRA (0.75) | PDE4BMEN1KMT2AESRRAFOXM1 | |
| SCHEMBL23496327 | 0.88 | ADAMTS5 (0.79) | CISD1PDE4BPDE3AMEN1KMT2A | |
| SCHEMBL23496326 | 0.88 | ADAMTS5 (0.79) | CISD1PDE4BPDE3AMEN1KMT2A | |
| SCHEMBL2697148 | 0.87 | ESRRA (0.64) | PDE4BMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL2697151 | 0.87 | ESRRA (0.64) | PDE4BMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL2201951 | 0.86 | FOXM1 (0.64) | CISD1MEN1KMT2AADAMTS5ESRRA | |
| SCHEMBL23496315 | 0.85 | CISD1 (0.76) | CISD1PDE4BPDE3AMEN1KMT2A | |
| SCHEMBL23496313 | 0.85 | CISD1 (0.76) | CISD1PDE4BPDE3AMEN1KMT2A | |
| SCHEMBL5613820 | 0.84 | CA2 (0.61) | CISD1PDE4BPDE3AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977489-B2 | Benzylthiazolone inhibitors of estrogen-related receptors (ERR) | EXELIXIS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-7977489-B2 | Benzylthiazolone inhibitors of estrogen-related receptors (ERR) | EXELIXIS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20090197870-A1 | Pharmaceutical Compositions | EXELIXIS, INC. (US) | 2009-08-06 | — | — | US | disclosed |
| US-20090197870-A1 | Pharmaceutical Compositions | EXELIXIS, INC. (US) | 2009-08-06 | — | — | US | disclosed |
| EP-1805154-A2 | PHARMACEUTICAL COMPOSITIONS | Exelixis, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006047269-A2 | PHARMACEUTICAL COMPOSITIONS | EXELIXIS, INC. (US) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197870-A1 | Pharmaceutical Compositions | ESRRA, ESRRB, ESR2 | CISD1 4710/4885PDE4B 721/4885PDE3A 661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.