Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOXM1 | Q08050 | 1/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.60 |
| ▸ | MMP3 | P08254 | 1/20 | 0.58 |
| ▸ | MMP13 | P45452 | 1/20 | 0.58 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.56 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | CTSD | P07339 | 8/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.51 |
| ▸ | ESRRA | P11474 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971175 | 0.87 | MMP3 (0.67) | FOXM1PTPN1MMP3MMP13ADAMTS5 | |
| SCHEMBL7971179 | 0.87 | MMP3 (0.67) | FOXM1PTPN1MMP3MMP13ADAMTS5 | |
| SCHEMBL2200573 | 0.86 | CISD1 (0.65) | FOXM1ADAMTS5CISD1DYRK1AMEN1 | |
| SCHEMBL4058937 | 0.84 | PTPN1 (0.83) | FOXM1PTPN1MMP3MMP13ADAMTS5 | |
| SCHEMBL4058938 | 0.84 | PTPN1 (0.83) | FOXM1PTPN1MMP3MMP13ADAMTS5 | |
| SCHEMBL5613820 | 0.84 | CA2 (0.61) | FOXM1PTPN1ADAMTS5CISD1DYRK1A | |
| SCHEMBL2698909 | 0.80 | FOXM1 (0.61) | FOXM1PTPN1ESRRA | |
| SCHEMBL2698902 | 0.80 | FOXM1 (0.61) | FOXM1PTPN1ESRRA | |
| SCHEMBL2699394 | 0.80 | HPGD (0.62) | FOXM1PTPN1 | |
| SCHEMBL2699391 | 0.80 | HPGD (0.62) | FOXM1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977489-B2 | Benzylthiazolone inhibitors of estrogen-related receptors (ERR) | EXELIXIS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20090197870-A1 | Pharmaceutical Compositions | EXELIXIS, INC. (US) | 2009-08-06 | — | — | US | disclosed |
| EP-1805154-A2 | PHARMACEUTICAL COMPOSITIONS | Exelixis, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006047269-A2 | PHARMACEUTICAL COMPOSITIONS | EXELIXIS, INC. (US) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197870-A1 | Pharmaceutical Compositions | ESRRA, ESRRB, ESR2 | FOXM1 281/4885PTPN1 1203/4885MMP3 4306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.