Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | LOX | P28300 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL662664 | 0.84 | NOS3 (0.53) | NOS2NOS3NOS1SMYD3KDM4E | |
| SCHEMBL9000442 | 0.81 | NOS3 (0.47) | NOS2NOS3NOS1SMYD3KDM4E | |
| SCHEMBL25520641 | 0.80 | ESR1 (0.33) | NOS2NOS3NOS1APLNRLOX | |
| SCHEMBL6642166 | 0.78 | NOS3 (0.52) | NOS2NOS3NOS1SMYD3KDM4E | |
| SCHEMBL20621291 | 0.78 | NOS3 (0.52) | NOS2NOS3NOS1SMYD3KDM4E | |
| SCHEMBL1972140 | 0.78 | NOS3 (0.52) | NOS2NOS3NOS1SMYD3KDM4E | |
| SCHEMBL9756830 | 0.78 | PTGS2 (0.44) | NOS2NOS3NOS1SMYD3KDM4E | |
| SCHEMBL9756832 | 0.78 | PTGS2 (0.44) | NOS2NOS3NOS1SMYD3KDM4E | |
| SCHEMBL23015846 | 0.76 | NOS3 (0.46) | NOS2NOS3NOS1SMYD3KDM4E | |
| SCHEMBL12656983 | 0.76 | NOS3 (0.42) | NOS2NOS3NOS1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209651-B9 | CARBAZOLE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2020-05-20 | — | — | EP | disclosed |