Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 4/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442104 | 0.87 | HTT (0.53) | HPGDSSMN1; SMN2ADORA3KMT2AKDM4E | |
| SCHEMBL2197680 | 0.85 | PDE4D (0.40) | CDK5CDK5R1ALDH1A1HPGDHPGDS | |
| SCHEMBL2200266 | 0.82 | PDE4D (0.58) | ALDH1A1HPGDHSD17B10CDC7DBF4 | |
| SCHEMBL10920620 | 0.80 | ALDH1A1 (0.49) | ALDH1A1HPGDHSD17B10CDC7DBF4 | |
| SCHEMBL10921097 | 0.80 | ALDH1A1 (0.49) | ALDH1A1HPGDHSD17B10CDC7DBF4 | |
| SCHEMBL25211948 | 0.80 | ALDH1A1 (0.55) | ALDH1A1HPGDHSD17B10CDC7DBF4 | |
| SCHEMBL2201791 | 0.77 | PDE4D (0.63) | ALDH1A1HPGDHSD17B10SMN1; SMN2ADORA3 | |
| SCHEMBL17129029 | 0.72 | DUSP3 (0.48) | ALDH1A1HPGDHSD17B10CDC7DBF4 | |
| SCHEMBL20471495 | 0.72 | KDM4E (0.50) | ALDH1A1HPGDSMN1; SMN2LMNAKMT2A | |
| SCHEMBL6726705 | 0.71 | CDC7 (0.49) | CDK5CDK5R1ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |
| EP-2182953-A2 | NEW PYRAZOL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-05-12 | — | — | EP | disclosed |
| US-20090029963-A1 | PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | US | disclosed |
| WO-2009013211-A2 | NEW PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029963-A1 | PYRAZOL DERIVATIVES | CCR1, CCR3, CCRL2 | CDK5 464/4885CDK5R1 210/4885MAPK11 955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.