SCHEMBL6726705

SCHEMBL6726705

CCOC(=O)c1nc(=O)c(-c2ccncc2)n[nH]1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC7 O00311 10/20 0.49
DBF4 Q9UBU7 9/20 0.49
HPGDS O60760 1/20 0.47
KDM4E B2RXH2 1/20 0.46
MMP2 P08253 1/20 0.45
MMP13 P45452 1/20 0.45
MMP14 P50281 1/20 0.45
ALDH1A1 P00352 1/20 0.45
HPGD P15428 1/20 0.45
HSD17B10 Q99714 1/20 0.45
ALOX5 P09917 1/20 0.45
NPSR1 Q6W5P4 2/20 0.44
PKN1 Q16512 1/20 0.44
PKN2 Q16513 1/20 0.44
MAPK1 P28482 1/20 0.44
USP2 O75604 1/20 0.43
TP53 P04637 1/20 0.43
GAA P10253 1/20 0.43
HKDC1 Q2TB90 1/20 0.43
CDK5 Q00535 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6726345 0.79 PDE1A (0.40) CDC7DBF4KDM4EALDH1A1HPGD
SCHEMBL2200266 0.77 PDE4D (0.58) CDC7DBF4HPGDSKDM4EMMP2
SCHEMBL22299598 0.75 PKN1 (0.51) CDC7DBF4HPGDSKDM4EMMP2
SCHEMBL10921097 0.75 ALDH1A1 (0.49) CDC7DBF4HPGDSKDM4EMMP2
SCHEMBL10920620 0.75 ALDH1A1 (0.49) CDC7DBF4HPGDSKDM4EMMP2
SCHEMBL25211948 0.75 ALDH1A1 (0.55) CDC7DBF4HPGDSKDM4EMMP2
SCHEMBL17129029 0.75 DUSP3 (0.48) CDC7DBF4HPGDSKDM4EMMP2
SCHEMBL5542779 0.74 GAA (0.51) CDC7DBF4KDM4EMMP2MMP13
SCHEMBL2200905 0.71 CDK5 (0.46) CDC7DBF4HPGDSKDM4EALDH1A1
SCHEMBL20487853 0.70 MMP2 (0.52) CDC7DBF4KDM4EMMP2MMP13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6747023-B1 INHIBITORS FOR ACTIVATED COAGULATION FACTOR X, COAGULATION SUPPRESSORS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-06-08 US disclosed
US-20040082611-A1 Anticoagulants; brain disorders; respiratory system disorders; side effect reduction DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-04-29 US disclosed
EP-1104754-A1 NOVEL SULFONYL DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2001-06-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040082611-A1 Anticoagulants; brain disorders; respiratory system disorders; side effect reduction F2, CYC1, SULT2A1 CDC7 4311/4885DBF4 3902/4885HPGDS 859/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.