Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 10/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL92265 | 0.74 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTPOLBPARP1 | |
| SCHEMBL11737600 | 0.69 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTPOLBPARP1 | |
| SCHEMBL13963735 | 0.66 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTPOLBKDM4E | |
| Ticlatone SCHEMBL193888 | 0.65 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTPOLBPARP1 | |
| Ticlatone SCHEMBL30165586 | 0.65 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTPOLBPARP1 | |
| SCHEMBL5807922 | 0.65 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTPOLBPARP1 | |
| SCHEMBL6406734 | 0.65 | PARP1 (0.77) | ALDH1A1PARP1KDM4EHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL11779389 | 0.64 | HRH3 (0.57) | ALDH1A1POLBKDM4EHTTHRH3 | |
| SCHEMBL11201497 | 0.62 | HRH3 (0.94) | ALDH1A1POLBKDM4EHRH3SMN1; SMN2 | |
| SCHEMBL22010268 | 0.62 | CHKA (0.40) | ALDH1A1POLBPARP1HTTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880666-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-06-28 | — | — | EP | disclosed |
| WO-2020102100-A9 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2022-01-06 | — | — | WO | disclosed |
| WO-2020102100-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |