Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 5/20 | 0.69 |
| ▸ | CASP3 | P42574 | 15/20 | 0.52 |
| ▸ | TERT | O14746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22010604 | 0.92 | NR4A1 (0.69) | NR4A1CASP3TERT | |
| SCHEMBL22010869 | 0.90 | NR4A1 (0.62) | NR4A1CASP3TERT | |
| SCHEMBL22010606 | 0.90 | NR4A1 (0.84) | NR4A1CASP3TERT | |
| SCHEMBL22010975 | 0.89 | NR4A1 (0.61) | NR4A1CASP3TERT | |
| SCHEMBL22010858 | 0.89 | NR4A1 (0.66) | NR4A1CASP3TERT | |
| SCHEMBL22010993 | 0.89 | CASP3 (0.60) | NR4A1CASP3 | |
| SCHEMBL22010992 | 0.89 | NR4A1 (0.56) | NR4A1CASP3TERT | |
| SCHEMBL26208654 | 0.89 | NR4A1 (0.58) | NR4A1CASP3TERT | |
| SCHEMBL23054483 | 0.88 | NR4A1 (0.62) | NR4A1CASP3TERT | |
| SCHEMBL22010887 | 0.88 | NR4A1 (0.58) | NR4A1CASP3TERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753436-B2 | Analogs of celastrol | ERX PHARMACEUTICALS CORPORATION (US) | 2023-09-12 | — | — | US | disclosed |
| US-20210061851-A1 | ANALOGS OF CELASTROL | ERX PHARMACEUTICALS CORPORATION | 2021-03-04 | — | — | US | disclosed |
| US-10662218-B2 | Analogs of celastrol | ERX PHARMACEUTICALS CORPORATION | 2020-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210061851-A1 | ANALOGS OF CELASTROL | GIPR, GPR119, EBP | NR4A1 1945/4885CASP3 247/4885TERT 3225/4885 |
| US-10662218-B2 | Analogs of celastrol | GIPR, GPR119, EBP | NR4A1 1945/4885CASP3 247/4885TERT 3225/4885 |
| US-11753436-B2 | Analogs of celastrol | GIPR, GPR119, EBP | NR4A1 1945/4885CASP3 247/4885TERT 3225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.