Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 19/20 | 0.60 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.58 |
| ▸ | CDC37 | Q16543 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22010604 | 0.92 | NR4A1 (0.69) | CASP3NR4A1HSP90AB1CDC37 | |
| SCHEMBL22010869 | 0.91 | NR4A1 (0.62) | CASP3NR4A1HSP90AB1CDC37 | |
| SCHEMBL22010975 | 0.90 | NR4A1 (0.61) | CASP3NR4A1HSP90AB1CDC37 | |
| SCHEMBL18782169 | 0.90 | CASP3 (0.73) | CASP3NR4A1HSP90AB1CDC37 | |
| SCHEMBL26210798 | 0.90 | CASP3 (0.73) | CASP3NR4A1HSP90AB1CDC37 | |
| SCHEMBL22010858 | 0.90 | NR4A1 (0.66) | CASP3NR4A1HSP90AB1CDC37 | |
| SCHEMBL23054483 | 0.89 | NR4A1 (0.62) | CASP3NR4A1HSP90AB1CDC37 | |
| SCHEMBL22010887 | 0.89 | NR4A1 (0.58) | CASP3NR4A1HSP90AB1CDC37 | |
| SCHEMBL22010608 | 0.89 | NR4A1 (0.69) | CASP3NR4A1 | |
| SCHEMBL22011117 | 0.89 | NR4A1 (0.58) | CASP3NR4A1HSP90AB1CDC37 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662218-B2 | Analogs of celastrol | ERX PHARMACEUTICALS CORPORATION | 2020-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662218-B2 | Analogs of celastrol | GIPR, GPR119, EBP | CASP3 247/4885NR4A1 1945/4885HSP90AB1 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.