Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28604432 | 0.97 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL24220741 | 0.91 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL28919216 | 0.91 | HPGD (0.43) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL24220807 | 0.89 | MEN1 (0.43) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL28607247 | 0.89 | MEN1 (0.43) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL22011473 | 0.89 | MEN1 (0.45) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL24220724 | 0.88 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL22010658 | 0.88 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL28604431 | 0.88 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL21964077 | 0.87 | L3MBTL1 (0.42) | ALDH1A1MEN1KMT2AMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020099882-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS | THE UNIVERSITY OF SHEFFIELD (GB) | 2020-05-22 | — | — | WO | disclosed |