Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22010639 | 0.84 | NPY5R (0.53) | POLBSMN1; SMN2RAB9ALMNANPC1 | |
| SCHEMBL20020537 | 0.84 | NPY5R (0.53) | POLBSMN1; SMN2RAB9ALMNANPC1 | |
| SCHEMBL20664267 | 0.81 | NPC1 (0.46) | SMN1; SMN2RAB9ALMNANPC1NPY5R | |
| SCHEMBL24982439 | 0.81 | NPC1 (0.46) | POLBRAB9ALMNANPC1NPY5R | |
| SCHEMBL22010868 | 0.81 | NPC1 (0.46) | POLBRAB9ALMNANPC1NPY5R | |
| SCHEMBL3671286 | 0.74 | HPGD (0.65) | SMN1; SMN2RAB9ALMNANPC1PKM | |
| SCHEMBL30355896 | 0.74 | HPGD (0.65) | SMN1; SMN2RAB9ALMNANPC1PKM | |
| SCHEMBL22011481 | 0.73 | ANO1 (0.44) | POLBRAB9ALMNANPC1PKM | |
| SCHEMBL10199545 | 0.72 | BRAF (0.61) | BRAFRAB9ANPC1MEN1KMT2A | |
| SCHEMBL17339950 | 0.72 | RAB9A (0.66) | RAB9ALMNANPC1PKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020099882-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS | THE UNIVERSITY OF SHEFFIELD (GB) | 2020-05-22 | — | — | WO | disclosed |