Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20020537 | 1.00 | NPY5R (0.53) | NPY5RNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL22010868 | 0.85 | NPC1 (0.46) | NPY5RNPC1RAB9AALDH1A1PKM | |
| SCHEMBL20664267 | 0.85 | NPC1 (0.46) | NPY5RNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL24982439 | 0.85 | NPC1 (0.46) | NPY5RNPC1RAB9AALDH1A1PKM | |
| SCHEMBL22011476 | 0.84 | POLB (0.46) | NPY5RNPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL3671286 | 0.77 | HPGD (0.65) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL30355896 | 0.77 | HPGD (0.65) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL10766608 | 0.76 | RAB9A (0.56) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL21132204 | 0.76 | AVPR1A (0.53) | — | |
| SCHEMBL22011481 | 0.76 | ANO1 (0.44) | NPC1RAB9AKDM4EALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020099882-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS | THE UNIVERSITY OF SHEFFIELD (GB) | 2020-05-22 | — | — | WO | disclosed |