Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 9/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 3/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22012907 | 0.82 | FBP1 (0.41) | — | |
| SCHEMBL22012118 | 0.79 | PARP1 (0.36) | PARP1PARP2 | |
| SCHEMBL6673498 | 0.76 | PNMT (0.54) | PNMTADRA2AADRA2BADRA2CPARP1 | |
| Hydrochloric Acid SCHEMBL21962263 | 0.75 | PNMT (0.53) | PNMTADRA2AADRA2BADRA2CPARP1 | |
| SCHEMBL30244132 | 0.74 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2CPARP1 | |
| SCHEMBL21962438 | 0.73 | PRMT5 (0.32) | — | |
| SCHEMBL22012113 | 0.72 | NR1H2 (0.45) | — | |
| SCHEMBL25031530 | 0.69 | KDM4D (0.32) | — | |
| SCHEMBL23569183 | 0.69 | PTGES2 (0.40) | — | |
| SCHEMBL20692370 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |