Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 10/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 6/20 | 0.42 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21962263 | 0.98 | PNMT (0.53) | PNMTADRA2AADRA2BADRA2CCA2 | |
| SCHEMBL30244132 | 0.87 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2CPARP1 | |
| SCHEMBL10647462 | 0.87 | PNMT (0.47) | PNMTADRA2AADRA2BADRA2CCA2 | |
| SCHEMBL22012074 | 0.76 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CPARP1 | |
| SCHEMBL29505746 | 0.75 | CA2 (0.54) | ADRA2AADRA2BADRA2CCA2 | |
| SCHEMBL29401046 | 0.75 | CA2 (0.54) | ADRA2AADRA2BADRA2CCA2 | |
| SCHEMBL21962121 | 0.73 | FBP1 (0.46) | CA2 | |
| SCHEMBL9429746 | 0.72 | CA2 (0.62) | CA2 | |
| SCHEMBL29746482 | 0.71 | CA2 (0.43) | PNMTADRA2AADRA2BADRA2CCA2 | |
| SCHEMBL10514334 | 0.71 | CA2 (0.43) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023116812-A1 | SULFONYLUREA COMPOUND | 瑞石生物医药有限公司 | 2023-06-29 | — | — | WO | disclosed |
| WO-2023116812-A1 | SULFONYLUREA COMPOUND | 瑞石生物医药有限公司 | 2023-06-29 | — | — | WO | disclosed |
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |
| WO-2004043369-A2 | SULFONAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2004-05-27 | — | — | WO | disclosed |