Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | ESRRA | P11474 | 12/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12431793 | 0.77 | ESRRA (0.43) | ESRRAMEN1NPC1USP2RAB9A | |
| SCHEMBL12431789 | 0.76 | ESRRA (0.44) | ESRRAMEN1NPC1USP2RAB9A | |
| SCHEMBL12431784 | 0.76 | ESRRA (0.47) | ESRRAMEN1NPC1USP2RAB9A | |
| SCHEMBL12431792 | 0.76 | ESRRA (0.44) | ESRRAMEN1NPC1USP2RAB9A | |
| SCHEMBL2199307 | 0.76 | ESRRA (0.44) | ESRRAMEN1NPC1USP2RAB9A | |
| SCHEMBL8310042 | 0.76 | CA2 (0.56) | CA2PTPN1MEN1KMT2ASIRT2 | |
| SCHEMBL2200573 | 0.76 | CISD1 (0.65) | ESRRAMEN1KMT2AFOXM1 | |
| SCHEMBL12431787 | 0.75 | L3MBTL1 (0.44) | ESRRAMEN1NPC1USP2RAB9A | |
| SCHEMBL8172766 | 0.75 | SIRT2 (0.68) | CA2PTPN1MEN1RAB9AKMT2A | |
| SCHEMBL8309358 | 0.75 | CA2 (0.52) | CA2PTPN1MEN1KMT2ASIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977489-B2 | Benzylthiazolone inhibitors of estrogen-related receptors (ERR) | EXELIXIS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20090197870-A1 | Pharmaceutical Compositions | EXELIXIS, INC. (US) | 2009-08-06 | — | — | US | disclosed |
| EP-1805154-A2 | PHARMACEUTICAL COMPOSITIONS | Exelixis, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006047269-A2 | PHARMACEUTICAL COMPOSITIONS | EXELIXIS, INC. (US) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197870-A1 | Pharmaceutical Compositions | ESRRA, ESRRB, ESR2 | CA2 1758/4885ESRRA 1/4885PTPN1 1203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.