SCHEMBL22012402

SCHEMBL22012402

CN(C)Cc1ccc([S+](N)[O-])c(F)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.38
ALDH1A1 P00352 2/20 0.35
TSHR P16473 2/20 0.35
LMNA P02545 1/20 0.35
GAA P10253 1/20 0.35
TAAR1 Q96RJ0 2/20 0.34
NOS1 P29475 2/20 0.34
HTR7 P34969 2/20 0.33
CA2 P00918 1/20 0.33
PRKACA P17612 1/20 0.33
PRKACG P22612 1/20 0.33
PRKACB P22694 1/20 0.33
NOS3 P29474 1/20 0.33
NOS2 P35228 1/20 0.33
P2RY1 P47900 1/20 0.33
TNKS O95271 1/20 0.33
MPO P05164 1/20 0.32
CYP2C9 P11712 1/20 0.32
ALOX15 P16050 1/20 0.32
HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22012064 0.76 HTR2C (0.36) P2RY1
SCHEMBL23972532 0.74 HRH3 (0.50) HRH3ALDH1A1TSHRLMNAGAA
SCHEMBL13862131 0.73 ALDH1A1 (0.45) HRH3ALDH1A1TSHRTAAR1NOS1
SCHEMBL5913371 0.71 HRH3 (0.39) HRH3ALDH1A1TSHRLMNAGAA
SCHEMBL20698712 0.71 HRH3 (0.52) HRH3ALDH1A1TSHRTAAR1NOS1
SCHEMBL8251603 0.71 HRH3 (0.46) HRH3ALDH1A1TSHRLMNAGAA
SCHEMBL20048654 0.71 NFE2L2 (0.34) ALDH1A1TSHRLMNATAAR1ALOX15
SCHEMBL21419317 0.70 ALDH1A1 (0.55) HRH3ALDH1A1TSHRLMNAGAA
SCHEMBL19674489 0.70 ALDH1A1 (0.44) ALDH1A1CA2
SCHEMBL24000519 0.70 DAO (0.36) ALDH1A1HTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020102576-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY NOVARTIS INFLAMMASOME RESEARCH, INC. (US) 2020-05-22 WO disclosed