Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 3/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.40 |
| ▸ | STS | P08842 | 2/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22012885 | 1.00 | NR1H2 (0.40) | NR1H2NR1H3STSCHRNA7GPR119 | |
| SCHEMBL21962575 | 0.83 | GPR119 (0.50) | NR1H2NR1H3STSCHRNA7GPR119 | |
| SCHEMBL22012883 | 0.79 | STS (0.43) | NR1H2NR1H3STSGPR119RIPK1 | |
| SCHEMBL21962692 | 0.78 | GPR119 (0.49) | NR1H2NR1H3CHRNA7GPR119RIPK1 | |
| SCHEMBL22012470 | 0.77 | NR1H2 (0.40) | NR1H2NR1H3STSGPR119RIPK1 | |
| SCHEMBL16409297 | 0.77 | CA2 (0.51) | NR1H2NR1H3STSCHRNA7GPR119 | |
| SCHEMBL22012905 | 0.76 | ALDH1A1 (0.39) | MEN1KMT2A | |
| SCHEMBL22013637 | 0.76 | ALDH1A1 (0.39) | MEN1KMT2A | |
| SCHEMBL25033880 | 0.74 | KMT2A (0.46) | NR1H2NR1H3STSRIPK1MEN1 | |
| SCHEMBL14880733 | 0.73 | NR1H2 (0.54) | NR1H2NR1H3RIPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |