Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22012961 | 0.75 | KDM4E (0.40) | GAACYP1A2KDM4EMAPK1 | |
| SCHEMBL21962269 | 0.72 | ACHE (0.35) | MAPK1 | |
| SCHEMBL21646660 | 0.71 | ALDH1A1 (0.36) | GAACYP1A2KDM4EMAPK1 | |
| SCHEMBL25842067 | 0.71 | NLRP3 (0.37) | GAACYP1A2KDM4EMAPK1 | |
| SCHEMBL22012481 | 0.67 | POLB (0.40) | GAAKDM4E | |
| SCHEMBL18029669 | 0.66 | NLRP3 (0.53) | — | |
| SCHEMBL22019806 | 0.66 | GAA (0.59) | GAACYP1A2KDM4EMAPK1 | |
| SCHEMBL29494713 | 0.65 | NLRP3 (0.51) | — | |
| Potassium SCHEMBL29676171 | 0.65 | NLRP3 (0.51) | — | |
| SCHEMBL25845405 | 0.65 | NLRP3 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |