Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6184493 | 0.77 | KDM4E (0.33) | KDM4EMAPT | |
| SCHEMBL2978037 | 0.75 | KDM4E (0.42) | KDM4EMAPTHSD17B10ALDH1A1EPAS1 | |
| SCHEMBL1255261 | 0.75 | KDM4E (0.40) | KDM4EALDH1A1CYP1A2 | |
| SCHEMBL4558894 | 0.73 | HTR2A (0.44) | KDM4EMAPTHSD17B10ALDH1A1DRD2 | |
| Hydrochloric Acid SCHEMBL3149408 | 0.73 | KDM4E (0.44) | KDM4EMAPTHSD17B10ALDH1A1EPAS1 | |
| SCHEMBL1545124 | 0.72 | KDM4E (0.49) | KDM4EMAPTHSD17B10ALDH1A1EPAS1 | |
| Hydrochloric Acid SCHEMBL1838069 | 0.71 | KDM4E (0.51) | KDM4EMAPTHSD17B10ALDH1A1EPAS1 | |
| SCHEMBL6801582 | 0.71 | SSTR4 (0.35) | DRD2 | |
| SCHEMBL2202390 | 0.71 | MAPT (0.44) | MAPTALDH1A1CYP2D6 | |
| SCHEMBL571789 | 0.69 | SLC18A3 (0.41) | KDM4EMAPTHSD17B10ALDH1A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926721-B1 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | MSD ITALIA SRL (IT) | 2016-05-04 | — | — | EP | disclosed |
| CN-102448943-A | 2, 4 -diaminopyrimidines for the treatment of diseases characterised by excessive or abnormal cell proliferation | BOEHRINGER INGELHEIM INT | 2012-05-09 | — | — | CN | disclosed |
| US-7977374-B2 | Thiophene and thiazole substituted trifluoroethanone derivatives as histone deacetylase (HDAC) inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-07-12 | — | — | US | disclosed |
| US-20090156591-A1 | Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-06-18 | — | — | US | disclosed |
| EP-1926721-A2 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007029035-A2 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-03-15 | — | — | WO | disclosed |
| EP-1558608-A1 | OXINDOLE SUBSTITUTED PIPERAZINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-08-03 | — | — | EP | disclosed |
| US-20040142933-A1 | Oxindole substituted piperazine derivatives | FORREST GEORGE WILLIAM (CA) | 2004-07-22 | — | — | US | disclosed |
| WO-2004037820-A1 | OXINDOLE SUBSTITUTED PIPERAZINE DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2004-05-06 | — | — | WO | disclosed |
| US-4968792-A | Psychotropic benzisothiazole derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156591-A1 | Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors | HDAC1, HDAC2, HDAC11 | KDM4E 217/4885MAPT 1028/4885HSD17B10 96/4885 |
| US-20040142933-A1 | Oxindole substituted piperazine derivatives | OPRK1, OPRD1, CNR1 | KDM4E 2198/4885MAPT 611/4885HSD17B10 1925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.